1. No More SharePoint Designer
No new version of SharePoint designer, but you can still use SharePoint Designer 2013 with SharePoint Server 2016.
2. Bye Bye SharePoint Foundation
There will be no SharePoint Foundation in SharePoint 2016. That means no more free SharePoint version. If anyone wants to test SharePoint, I would say, use office 365 free one month subscription.
3. No SQL Express
SharePoint will not install SQL express anymore. SharePoint will just install only SharePoint components. We will have to install separately either on the same server or in a different server.
4. Cursed ForeFront Identity Manager or FIM is gone
In 2016, you don’t have the FIM option anymore. The only option is AD import, which can’t be customized and of course you can’t write back anything to AD.
5. STSADM officially deprecated
As per Microsoft STSADM officially deprecated Now. I still remember, we used STSADM inside PowerShell commands to create site collections based on the custom site collection. In PowerShell, we can’t use same session to install WSP and to create site based on custom site definition.
6. Excel services is no more part of SharePoint 2016
Excel service is now part of Office Online Server 2016.
7. No blame game between WFE and APP Servers
In SP 2016, it is called users roles. In earlier versions, admin decides what the role of each servers are and he runs set of services. It was all based on documentation or Microsoft guide lines. In SP 2016, these documentations are converted in to code and wrapped as Roles. This makes farm better responsive and better utilization of server resources and of course less work for Admins.